Shahnaz Usman
RAK MHSU, UAE
Title: Formulation and in-vitro evaluation of montelukast oral disintegrating (5 mg) tablets: Effects of diluents
Biography
Biography: Shahnaz Usman
Abstract
Objective: The aim of the present study was to prepare ODT by using relatively a simple direct compression technique with
high mechanical strength while keeping the attributes of fast disintegration and dissolution to improve the bioavailability of
the drug.
Method: Mannitol and microcrystalline cellulose were studied as diluents in the same quantity for manufacture of montelukast
sodium tablet using crospovidone as super disintegrants and sodium bicarbonate as wicking agent. The blend was examined
for angle of repose, bulk and tapped density, compressibility index, and Hausner’s ratio. The drug-excipients interaction was
investigated by FTIR. After compression hardness, friability, disintegration and dissolution, all the formulations batches were
analyzed.
Results: It was found that microcrystalline cellulose was suitable diluent for tablets considering hardness, friability and
disintegration time. Ten formulations F1 to F10 were prepared by central composite methods (two level factorial designs) for
the selection of optimum concentration of disintegrants and diluents.
Conclusions: The overall results showed that crospovidone was the best super-disintegrant for showing the shortest
disintegration time while MCC was the good diluent in preparing montelukast Oro-dispersible tablet and this suggested the
possibility of utilizing the selected best formula (F2) in the preparation of Oro-dispersible tablet as a new dosage form for oral
administration.