Kampanart Huanbutta
Burapha University, Thailand
Title: Development and characterization of seed gums from Cassia fistula as disintegrating agent for fast disintegrating Thai cordial tablet
Biography
Biography: Kampanart Huanbutta
Abstract
Crude seed gum and their carboxymethyl derivatives from Cassia fistula seed was developed and characterized to apply
as the pharmaceutical disintegrant in fast disintegrating Thai cordial tablet. The chemical structure of crude gum was
chemically modified via carboxymethylation. Degree of substitution (DS) of carboxymethylated gums was determined.
Carboxymethylated gums with minimum and maximum DS values were chosen for further application. IR absorption spectra
of gum samples were observed to verify their chemical structure changes. In physical properties, the intrinsic viscosity and
swelling property of all gum samples were evaluated. The results showed that carboxymethylated gums had higher intrinsic
viscosity than those of crude gum. Moreover, they could swell and be soluble in cold water better than those of crude gums.
In conclusion, the modified gums from both plants could provide higher hardness and be better used than that crude gums
for fast disintegrating Thai cordial tablet. However, this is a preliminary assessment to expressing pharmaceutical application
possibility of these gums as disintegrants, diluents and drug release controlling agents.